Complex Inhibitory Mechanism of Glycomimetics with Heparanase

protein characterizationstructural biologyenzyme inhibition

27 June

Cassidy Whitefield, Yen Vo, Brett D Schwartz, Caryn Hepburn, F Hafna Ahmed, Hideki Onagi, Martin G Banwell, Keats Nelms, Lara R Malins and Colin J Jackson

Biochemistry, 2023

Dana Matthews

Complex Inhibitory Mechanism of Glycomimetics with Heparanase

P450-mediated dehydrotyrosine formation during WS9326 biosynthesis proceeds via dehydrogenation of a specific acylated dipeptide substrate

A broad-spectrum macrocyclic peptide inhibitor of the SARS-CoV-2 spike protein