Rendering Proteins Fluorescent Inconspicuously: Genetically Encoded 4‐Cyanotryptophan Conserves Their Structure and Enables the Detection of Ligand Binding Sites

Haocheng Qianzhu, Elwy H Abdelkader, Adarshi P Welegedara, Edan Habel, Nathan Paul, Rebecca L Frkic, Colin J Jackson, Thomas Huber, Gottfried Otting

Rendering Proteins Fluorescent Inconspicuously: Genetically Encoded 4‐Cyanotryptophan Conserves Their Structure and Enables the Detection of Ligand Binding Sites

Angewandte Chemie, 2025

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Exploring large protein sequence space through homology-and representation-based hierarchical clustering

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An increased copy number of glycine decarboxylase (GLDC) associated with psychosis reduces extracellular glycine and impairs NMDA receptor function