An increased copy number of glycine decarboxylase (GLDC) associated with psychosis reduces extracellular glycine and impairs NMDA receptor function

Maltesh Kambali, Yan Li, Petr Unichenko, Jessica A. Feria Pliego, Rachita Yadav, Jing Liu, Patrick McGuinness, Johanna G. Cobb, Muxiao Wang, Rajasekar Nagarajan, Jinrui Lyu, Vanessa Vongsouthi, Colin J. Jackson, Elif Engin, Joseph T. Coyle, Jaeweon Shin, Nathaniel W. Hodgson, Takao K. Hensch, Michael E. Talkowski, Gregg E. Homanics, Vadim Y. Bolshakov, Christian Henneberger and Uwe Rudolph*

An increased copy number of glycine decarboxylase (GLDC) associated with psychosis reduces extracellular glycine and impairs NMDA receptor function

Molecular Psychiatry, 2024