Structural Insights into a Side Chain Cross-Linking Biarylitide P450 from RiPP Biosynthesis

Cytochrome-P450structural biologymolecular dynamics
Written By Dana Matthews

Mathias H. Hansen*, Angus Keto, Maxine Treisman, Vishnu Mini Sasi, Laura Coe, Yongwei Zhao, Leo Padva, Caroline Hess, Victor Leichthammer, Daniel L. Machell, Ralf B. Schittenhelm, Colin J. Jackson, Julien Tailhades, Max Crüsemann, James J. De Voss, Elizabeth H. Krenske and Max J. Cryle*

Structural Insights into a Side Chain Cross-Linking Biarylitide P450 from RiPP Biosynthesis

ACS Catalysis, 2024

Dana Matthews
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An Engineered Biarylitide Cross-Linking P450 from RiPP Biosynthesis Generates Alternative Cyclic Peptides
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P450-mediated dehydrotyrosine formation during WS9326 biosynthesis proceeds via dehydrogenation of a specific acylated dipeptide substrate