An Engineered Biarylitide Cross-Linking P450 from RiPP Biosynthesis Generates Alternative Cyclic Peptides

Maxine Treisman, Laura Coe, Yongwei Zhao, Vishnu Mini Sasi, Jemma Gullick, Mathias H. Hansen, Aviva Ly, Victor Leichthammer, Caroline Hess, Daniel L. Machell, Ralf B. Schittenhelm, Joel Hooper, Colin J. Jackson, Julien Tailhades, James J. De Voss* and Max J. Cryle*

An Engineered Biarylitide Cross-Linking P450 from RiPP Biosynthesis Generates Alternative Cyclic Peptides

Organic Letters, 2024

Structural Insights into a Side Chain Cross-Linking Biarylitide P450 from RiPP Biosynthesis

Mathias H. Hansen*, Angus Keto, Maxine Treisman, Vishnu Mini Sasi, Laura Coe, Yongwei Zhao, Leo Padva, Caroline Hess, Victor Leichthammer, Daniel L. Machell, Ralf B. Schittenhelm, Colin J. Jackson, Julien Tailhades, Max Crüsemann, James J. De Voss, Elizabeth H. Krenske and Max J. Cryle*

Structural Insights into a Side Chain Cross-Linking Biarylitide P450 from RiPP Biosynthesis

ACS Catalysis, 2024

P450-mediated dehydrotyrosine formation during WS9326 biosynthesis proceeds via dehydrogenation of a specific acylated dipeptide substrate

Songya Zhang, Lin Zhang, Anja Greule, Julien Tailhades, Edward Marschall, Panward Prasongpholchai, Daniel J. Leng, Jingfan Zhang, Jing Zhu, Joe A. Kaczmarski, Ralf B. Schittenhelm, Oliver Einsle, Colin J. Jackson, Fabrizio Alberti, Andreas Bechthold, Youming Zhang, Manuela Tosin*, Tong Si*, and Max J. Cryle*

P450-mediated dehydrotyrosine formation during WS9326 biosynthesis proceeds via dehydrogenation of a specific acylated dipeptide substrate

Acta Pharmaceutica Sinica B, 2023