Ancestral reconstruction of polyethylene terephthalate degrading cutinases reveals a rugged and unexplored sequence-fitness landscape

plastic-degrading enzymesancestral sequence reconstructionprotein landscape analysisbiomathematicsprotein characterizationprotein engineeringprotein evolution
Written By Dana Matthews

Vanessa Vongsouthi, Rosemary Georgelin, Dana S Matthews, Jake Saunders, Brendon M Lee, Jennifer Ton, Adam M Damry, Rebecca L Frkic, Matthew A Spence, Colin J Jackson

Ancestral reconstruction of polyethylene terephthalate degrading cutinases reveals a rugged and unexplored sequence-fitness landscape

Science Advances, 2025

Dana Matthews
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