Ancestral reconstruction of polyethylene terephthalate degrading cutinases reveals a rugged and unexplored sequence-fitness landscape

Vanessa Vongsouthi, Rosemary Georgelin, Dana S Matthews, Jake Saunders, Brendon M Lee, Jennifer Ton, Adam M Damry, Rebecca L Frkic, Matthew A Spence, Colin J Jackson

Ancestral reconstruction of polyethylene terephthalate degrading cutinases reveals a rugged and unexplored sequence-fitness landscape

Science Advances, 2025

Computational and Experimental Exploration of Protein Fitness Landscapes: Navigating Smooth and Rugged Terrains

Mahakaran Sandhu, John Z Chen, Dana S Matthews, Matthew A Spence, Sacha B Pulsford, Barnabas Gall, Joe A Kaczmarski, James Nichols, Nobuhiko Tokuriki, Colin J Jackson

Computational and Experimental Exploration of Protein Fitness Landscapes: Navigating Smooth and Rugged Terrains

Biochemistry, 2025

Leveraging ancestral sequence reconstruction for protein representation learning

Dana S. Matthews, Matthew A. Spence, Adam C. Mater, James Nichols, Sacha B. Pulsford, Mahakaran Sandhu, Joe A. Kaczmarski, Charlotte M. Miton, Nobuhiko Tokuriki, Colin J. Jackson

Leveraging ancestral sequence reconstruction for protein representation learning

Nature Machine Intelligence, 2024