Ancestral reconstruction of polyethylene terephthalate degrading cutinases reveals a rugged and unexplored sequence-fitness landscape
Vanessa Vongsouthi, Rosemary Georgelin, Dana S Matthews, Jake Saunders, Brendon M Lee, Jennifer Ton, Adam M Damry, Rebecca L Frkic, Matthew A Spence, Colin J Jackson
Science Advances, 2025
Leveraging ancestral sequence reconstruction for protein representation learning
Dana S. Matthews, Matthew A. Spence, Adam C. Mater, James Nichols, Sacha B. Pulsford, Mahakaran Sandhu, Joe A. Kaczmarski, Charlotte M. Miton, Nobuhiko Tokuriki, Colin J. Jackson
Leveraging ancestral sequence reconstruction for protein representation learning
Nature Machine Intelligence, 2024
Increasing the Soluble Expression and Whole-Cell Activity of the Plastic-Degrading Enzyme MHETase through Consensus Design
Jake W Saunders, Adam M Damry, Vanessa Vongsouthi, Matthew A Spence, Rebecca L Frkic, Chloe Gomez, Patrick A Yates, Dana S Matthews, Nobuhiko Tokuriki, Malcolm D McLeod and Colin J Jackson*
Biochemistry, 2024
Improving plastic degrading enzymes via directed evolution
Yvonne Joho, Vanessa Vongsouthi, Chloe Gomez, Joachim S Larsen, Albert Ardevol and Colin J Jackson*
Improving plastic degrading enzymes via directed evolution
Protein Engineering, Design, & Selection, 2024
