Ancestral reconstruction of polyethylene terephthalate degrading cutinases reveals a rugged and unexplored sequence-fitness landscape
Vanessa Vongsouthi, Rosemary Georgelin, Dana S Matthews, Jake Saunders, Brendon M Lee, Jennifer Ton, Adam M Damry, Rebecca L Frkic, Matthew A Spence, Colin J Jackson
Science Advances, 2025
Leveraging ancestral sequence reconstruction for protein representation learning
Dana S. Matthews, Matthew A. Spence, Adam C. Mater, James Nichols, Sacha B. Pulsford, Mahakaran Sandhu, Joe A. Kaczmarski, Charlotte M. Miton, Nobuhiko Tokuriki, Colin J. Jackson
Leveraging ancestral sequence reconstruction for protein representation learning
Nature Machine Intelligence, 2024
Rugged fitness landscapes minimize promiscuity in the evolution of transcriptional repressors
Anthony T Meger, Matthew A Spence, Mahakaran Sandhu, Dana S Matthews, Jackie Chen, Colin J Jackson and Srivatsan Raman
Rugged fitness landscapes minimize promiscuity in the evolution of transcriptional repressors
Cell Systems, 2024
A broad-spectrum macrocyclic peptide inhibitor of the SARS-CoV-2 spike protein
Vito Thijssen, Daniel L. Hurdiss, Oliver J. Debski-Antoniak, Matthew A. Spence, Charlotte Franck, Alexander Norman, Anupriya Aggarwal, Nadia J. Mokiem, David A.A. van Dongen, Stein W Vermeir, Minglong Liu, Wentao Li, Marianthi Chatziandreou, Tim Donselaar, Wenjuan Du, Ieva Drulyte, Berend-Jan Bosch, Joost Snijder, Stuart G. Turville, Richard J. Payne, Colin J. Jackson, Frank J.M. van Kuppeveld*, Seino A.K. Jongkees*
A broad-spectrum macrocyclic peptide inhibitor of the SARS-CoV-2 spike protein
Proceedings of the National Academy of Sciences, 2023
